Bunyavanich S, et al. - Racial/ethnic disparities in TMPRSS2 gene–related activity in prostate tissue has been reported to have an association with disproportionately higher incidence of prostate cancer in Black men vs White men. Researchers here examined TMPRSS2 nasal gene expression in a racially/ethnically diverse cohort given the recognition of many factors contributing to COVID-19 health disparities. They conducted a cross-sectional study employing nasal epithelium obtained during 2015-2018 from individuals within the Mount Sinai Health System (New York, New York), a cohort which was previously examined. The cohort (n = 305) comprised 8.2% Asian individuals, 15.4% Black individuals, 26.6% Latino individuals, 9.5% individuals of mixed race/ethnicity, and 40.3% White individuals. Findings revealed significantly higher expression of TMPRSS2 in Black individuals vs other self-identified races/ethnicities.Higher nasal expression of TMPRSS2 may have contributed to the higher burden of COVID-19 among Black individuals given its essential role in SARS-CoV-2 entry. clinical trials are underway investigating the utility of TMPRSS2 inhibitors such as camostat mesylate for COVID-19 treatment. The finding of racial/ethnic disparities in TMPRSS2 expression highlights that such trials should include diverse participants and analyses stratified by race/ethnicity.