Kcomt L, Evans-Polce RJ, Engstrom CW, et al. - This study evaluated the association between exposure to different forms of discrimination, such as racial/ethnic discrimination and sexual orientation discrimination, and severity of tobacco use disorder (TUD). To analyze the relationships among racial/ethnic discrimination, sexual orientation discrimination, and TUD severity for lesbian/gay-, bisexual-, and heterosexual-identified adults, researchers performed multivariable logistic regression analyses using data from the 2012–2013 National Epidemiologic Survey of Alcohol and Related Conditions-III (n=36,309 US adults). Among both sexual minorities and heterosexuals, higher levels of lifetime racial/ethnic discrimination were linked with significantly greater odds of past-year moderate-to-severe TUD; stressful life events, mood disorder, and anxiety disorder also had significant links with moderate-to-severe TUD in both of these populations. Higher levels of racial/ethnic and/or sexual orientation discrimination were associated with greater odds of any TUD among sexual minorities. The data highlighted that health providers and tobacco cessation professionals should be cognizant of the minority stressors experienced by their clients and their potential impact on TUD severity.