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Racial/ethnic differences in treatment and mortality among patients with triple-negative breast cancer

JAMA May 28, 2021

Cho B, Han Y, Lian M, et al. - Researchers analyzed a nationally representative cohort of patients with triple-negative breast cancer (TNBC), to assess the disparities in clinical treatment and outcomes between African American and White women in this population-based, retrospective cohort study. They also investigated the contributions of sociodemographic, clinical, and neighborhood factors to TNBC outcome differences. Participants were 23,123 women diagnosed with nonmetastatic TNBC between January 1, 2010, and December 31, 2015, and selected from the Surveillance, Epidemiology, and End Results dataset. Following adjustment for sociodemographic, clinicopathologic, and county-level factors, there were lower odds of undergoing surgery and chemotherapy in African American patients, relative to White patients. Findings revealed a significantly higher risk of breast cancer mortality in African American females with nonmetastatic TNBC vs their White counterparts, which was in part explained by their differences in receipt of surgery and chemotherapy.

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