Shorter JM, Koelper N, Sonalkar S, et al. - Researchers examined how depression symptoms among participants in an early pregnancy loss clinical trial differed by race. A planned secondary analysis of a randomized trial was performed by comparing treatments for medical management of early pregnancy loss. In the original trial, 300 participants diagnosed with a nonviable intrauterine pregnancy from 5 to 12 weeks of gestation were randomized from May 2014 to April 2017. This analysis was performed including 275 respondents comprising 120 [44%] self-identified as Black and 155 [56%] self-identified as non-Black. Overall findings revealed an increased risk for major depression 30 days after treatment in approximately one quarter of women who experience an early pregnancy loss. Relative to non-Black women, Black women exhibited nearly twice high risk. Appropriate mental health resources are required to manage women undergoing early pregnancy loss care.