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Racial and ethnic differences in sarcoma incidence are independent of census-tract socioeconomic status

Cancer Epidemiology, Biomarkers & Prevention Sep 18, 2020

Diessner BJ, Weigel BJ, Murugan P, et al. - Researchers examined the links between census tract-level socioeconomic status (CT-SES) and race/ethnicity on the incidence rates of sarcoma. For this purpose, they used the Surveillance, Epidemiology and End Results program. Employing quasi-Poisson models, stratified by wide age groups (pediatric: < 20 years, Adult: 20 - 65 years, Older adult: 65 + years) and adjusted for gender, age and year of diagnosis, experts estimated incidence rate ratios and 99% confidence intervals. This analysis involved 55,415 sarcoma cases in 35 sarcoma subtype-age group combinations. A statistically significant link of increasing CT-SES with 11 subtype-age group combinations was observed, mainly in the older age group strata (8 subtypes), while malignant peripheral nerve sheath tumors in adults were found to be related to declining CT-SES. Findings showed a more frequent link of race/ethnicity with sarcoma incidence than CT-SES. A likely stronger role of genetic variation related to ancestry, vs area-level SES-related factors, was suggested in the etiology of sarcoma.

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