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Race–ethnic differences in the associations of maternal lipid trait genetic risk scores with longitudinal fetal growth

Journal of Clinical Lipidology Jul 26, 2019

Ouidir M, et al. - Among 4 US racial–ethnic populations (Whites, Blacks, Hispanics, and Asians), researchers focused on the link between maternal lipid genetic risk score (GRS) and fetal growth. To calculate GRS, they used 240 single-nucleotide polymorphisms previously related to higher total cholesterol, low-density lipoprotein cholesterol, and triglycerides (GRSTG) and lower high-density lipoprotein cholesterol. They found 11.4 g higher fetal weight among normal-weight Whites, 26.3 g and 30.8 g among obese Blacks and among obese Hispanics, respectively, in relation to a unit increase in GRSTG, at 40 weeks’ gestation. Variations in the links between fetal weight and maternal lipid GRS by maternal race–ethnic group, obesity status, and offspring sex were seen in this study. Findings revealed the contribution of genetic susceptibility to unfavorable lipid profiles to fetal growth differences even among normal-weight women, indicating a potential future application in predicting aberrant fetal growth.
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