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Race and risk of subsequent aggressive breast cancer following ductal carcinoma in situ

Cancer May 30, 2019

Liu Y, et al. - Researchers investigated how the risk of developing aggressive invasive breast cancer (IBC) after ductal carcinoma in situ (DCIS) varies by race. For this purpose, they used the Surveillance, Epidemiology, and End Results data sets and selected women (n=163,892; 10.5% black, 9.8% Asian, and 8.6% Hispanic) with incident DCIS. They found that for black women and for Asian women, the adjusted hazards ratio of subsequent estrogen receptor (ER)–progesterone receptor (PR)– breast cancer was 1.86 and 1.40, respectively, vs white women, stronger than the links for ER+ and/or PR+ subtypes. Overall, higher risks of developing biologically aggressive IBC were observed among black and Asian women with DCIS vs white counterparts. While making treatment decisions for these patients with DCIS, these findings should be taken into account.

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