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Race and ethnicity predict bone markers and fracture in pediatric patients with chronic kidney disease

Journal of Bone and Mineral Research Sep 25, 2020

Laster M, Denburg M, Okuda Y, et al. - This study was sought to present whether race and ethnicity prognosticate bone markers and fracture in pediatric patients with chronic kidney disease. Researchers conducted a cohort study including a total of 762 children between the ages of 1.5 years and 18 years, with CKD stages 1‐4 from the CKD in children (CKiD) cohort to ascertain the association between racial‐ethnic group and bone markers (parathyroid hormone [PTH], 25‐hydroxyvitamin D [25‐OHD], 1,25‐dihydroxyvitamin D [1,25(OH)2D] and c‐terminal fibroblast growth factor) using linear mixed models. They applied logistic regression to assess racial‐ethnic variations in prevalent fracture upon study entry. The data exhibited that race and ethnicity are correlated with variations in bone markers and despite lower 25‐OHD levels, both African American and Hispanic children with CKD reported a lower prevalent fracture history than Caucasian children. The recent data in the CKD population are similar to racial‐ethnic variations described in healthy children. Future trials are required to better understand how these variations might impact the management of pediatric CKD‐MBD.

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