Race and ethnicity predict bone markers and fracture in pediatric patients with chronic kidney disease
Journal of Bone and Mineral Research Oct 30, 2020
Laster M, Denburg M, Okuda Y, et al. - Researchers conducted the study for analyzing the effect of race and ethnicity on bone markers and fractures within the pediatric chronic kidney disease (CKD) population. The relationship between racial‐ethnic group and bone markers (parathyroid hormone [PTH], 25‐hydroxyvitamin D [25‐OHD], 1,25‐dihydroxyvitamin D [1,25(OH)2D], and C‐terminal fibroblast growth factor [FGF23]) was calculated using linear mixed models in a cohort study of 762 children between the ages of 1.5 years and 18 years, with CKD stages 1 to 4 from the CKD in children (CKiD) cohort. Logistic regression was also used to assess racial‐ethnic disparities in prevalent fracture upon study entry. Race and ethnicity are correlated with bone marker variations, and both black and Hispanic children with CKD have reported a lower prevalence of fracture history than white children, despite lower 25-OHD levels. In the CKD population, the current results are close to the racial-ethnic differences reported in healthy children.
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