Hsu S, Hoofnagle AN, Gupta DK, et al. - In a cross-sectional study within the Multi-Ethnic Study of Atherosclerosis (MESA), researchers sought to describe racial/ethnic differences in vitamin D metabolism markers and their correlations with genetic ancestry. They contrasted a comprehensive panel of vitamin D metabolism markers across self-reported racial/ethnic groups of Black (N = 1,759), White (N = 2,507), Chinese (N = 788), and Hispanic (N = 1,411). Findings suggested an association of higher percent European ancestry with higher 25-hydroxyvitamin D and lower parathyroid hormone concentrations among Black and Hispanic candidates. Vitamin D metabolism markers differ significantly by race/ethnicity, can serve to maintain bone and mineral homeostasis across ranges of 25-hydroxyvitamin D production, and be attributable, at least partly, to genetic ancestry.