Hong IH, et al. – This study focused on analyzing the response of antivascular endothelial growth factor treatment in patients with neovascular diseases. Favorable functional outcomes achieved using current quantitative methods would lend additional confidence to the effectiveness of a treat–and–extend protocol through the intravitreal anti–VEGF, for the management of such patients. Regardless of the antivascular endothelial growth factor's (anti–VEGF) wide use, a well–designed longitudinal multicenter study to systematically assess and compare different physiological methods or parameters in patients with neovascular diseases appeared to be lacking. However, it would benefit therapeutic decisions.