Zhou LJ, Luo XZ, Shen PY, et al. - Researchers conducted this prospective, cross-sectional study to examine the superficial vessel density (VD) of the papillary microvasculature and its determinants in healthy individuals of Southern China. Optical coherence tomography angiography was used to assess superficial VD in the optic disc region of healthy people. Using a generalized estimation equation model, the factors associated with ocular and systemic parameters were analyzed. In total, 510 eyes of 260 healthy individuals were analyzed in the study. In healthy individuals, the mean total VD in the optic disc area was 17.21 ± 2.15 mm ^− 1, with the superior and inferior VDs being slightly higher than the temporal and nasal VDs. The total VD in the optic disc area can be affected by axial length, disc area, central macular thickness, and signal strength index, all of which should be considered in clinical practice.