Pencina MJ, et al. - In a cohort of 22,626 individuals (aged 45 to 84 years) who were initially free of cardiovascular disease, researchers assessed how crucial modifiable coronary heart disease (CHD) risk factors—particularly lipids, systolic blood pressure, diabetes mellitus, and smoking—correlated with incident CHD events based on their prognostic ability, attributable risk fractions, and treatment benefits, both overall and by age. Using four observational National Heart, Lung, and Blood Institute-sponsored cohort studies, they pooled participant-level data. Participants were observed from baseline evaluation for incident CHD for 10 years. Only a modest contribution of individual modifiable CHD risk factors to prognostic ability was evident, but according to the models, substantial attenuations in total population CHD events would be achieved by eradicating or limiting these individual factors.