Philips R, Agarwal A, Chitguppi C, et al. - This retrospective chart review was performed to determine multidimensional quality of life (QOL) results among patients suffering from sinonasal malignancies (SNM). Researchers investigated factors predicting worse QOL in this population. They analyzed 81 patients who satisfied the inclusion criteria. They assessed QOL outcomes by employing the Hospital Anxiety and Depression Scale (HADS) and the Functional Assessment Cancer Therapy – Nasopharynx (FACT-NP) score. A subscale score >11 for anxiety (HADS-A) or depression (HADS-D) indicating significant anxiety or depression was found in 12 (14.8%) patients, at a median of 24 (8–68.5) months after treatment. Advanced T classification and single relationship status were revealed as significant predictors of anxiety and depression (based on HADS), post-adjustment for confounders, at a median of 24 months after completion of definitive therapy for SNM. Worse anxiety, depression, and QOL (based on HADS and FACT-NP) were evident in relation to a worse social support survey score. Early detection of these factors may assist in guiding treatment and psychiatric referral to at-risk people post-treatment of SNM.