Thomas AJ, Mace JC, Ramakrishnan VR, et al. - In this observational, multi-institutional study, researchers described changes in clinically measured olfactory function (Sniffin’ Sticks), and patient-reported QOL outcomes (22-item Sino-Nasal Outcome Test [SNOT-22], Questionnaire of Olfactory Disorders–Negative Statements [QOD-NS]) after a short course of appropriate medical therapy (AMT). In addition, they explored the connection between changes in the patient-reported outcomes (SNOT-22 and QOD-NS) and clinically measured outcomes (Sniffin’ Sticks and endoscopy scores). For this analysis, they prospectively involved adults with symptomatic chronic rhinosinusitis [CRS] (November 2016 to October 2018). According to results, baseline measures showed heterogeneity of QOL and olfactory dysfunction (OD). Candidates with varied impacts of CRS, treated with individualized short-term AMT, showed significant improvements in CRS- and olfactory-specific QOL measures, without a corresponding improvement in clinically measured olfactory function. Olfactory function changes moderately correlated with changes in the endoscopy score but lacked a connection to QOL measurements.