Pubertal growth and adult height in relation to breast cancer risk in African American women
International Journal of Cancer Sep 01, 2017
Bertrand KA et al. - In the current study, height was shown to be a strong risk factor for ER+ breast cancer in African American women. Early age at attained height was shown to be a risk factor for both ER+ and ER- breast cancer. Furthere, adult height and timing of pubertal growth were shown to be inter-related, but independent risk factors for breast cancer.
Methods
The associations between adult height, age at attained height, and age at menarche with incidence of invasive breast cancer was determined in 55,687 African American women in the prospective Black Women's Health Study.
Results
Over 20 years, 1,826 invasive breast cancers (1015 ER+ and 542 ER-) were accrued.
Adult height was associated with an increased risk of ER+ breast cancer (HR = 1.44 for height greater than or equal to 70 inches vs. less than or equal to 63 inches), but not ER- (HR = 1.16).
HRs for attained height before age 13 vs. age >17 were 1.30 for ER+ and 1.25 for ER- breast cancer.
Results for age at menarche (less than or equal to 11 years vs. greater than or equal to 14 years) were similar for ER+ and ER- breast cancer (HR for breast cancer overall = 1.30).
-
Exclusive Write-ups & Webinars by KOLs
-
Daily Quiz by specialty
-
Paid Market Research Surveys
-
Case discussions, News & Journals' summaries