Bekfani T, Nisser J, Derlien S, et al. - This study sought to compare quality-of-life (QoL), depression, and anxiety scores among outpatients with preserved (HFpEF) and reduced (HFrEF) ejection fraction and non-HF controls and its relationship to coordination capacity. Researchers enrolled a total of 55 individuals prospectively at the University Hospital Jena, Germany (17 HFpEF, 18 HFrEF, and 20 non-HF controls). Using the short form of health survey, and hospital anxiety and depression scale, all participants had undergone echocardiography, cardiopulmonary exercise testing, 10 m walking test, isokinetic muscle function and coordination tests, and QoL assessments. In comparison with HFrEF and non-HF controls, outpatients with HFpEF had worse QoL and higher anxiety and depression scores. It was shown that depression is correlated with reduced QoL and is an independent predictor for reduced coordination capacity.