Honda Y, Mok Y, Mathews L, et al. - In the Atherosclerosis Risk in Communities Study, researchers sought to compare links of psychosocial factors with the risk of peripheral artery disease (PAD) and two other major atherosclerotic cardiovascular disease (CVD): coronary heart disease (CHD) and ischemic stroke. Four psychosocial domains were assessed: depressive/fatigue symptoms using the Maastricht Questionnaire, social support employing the Interpersonal Evaluation List, social networks via the Lubben Scale, and trait anger by the Spielberger Scale. Participants were 11,104 individuals (mean age 56.7 [SD 5.7] years) without a clinical history of PAD and CHD/stroke at baseline (1990-1992). Findings revealed an independent link of depressive/fatigue symptoms and social support (especially the former) with the risk of hospitalizations with PAD but not CHD/stroke in the general population. According to findings, depressive/fatigue symptoms hold importance in vascular health, and there is a requirement of incorporating PAD when examining the influence of psychosocial factors on CVD.