Kummer S, Waller J, Ruparel M, et al. - Researchers assessed the psychological burden in low-dose CT (LDCT) lung cancer screening trials. Within a real-world screening demonstration pilot, current and former smokers (n = 787, aged 60–75) were assessed at three time points (T0: appointment, T1: next day, T2: 3 months) for measures of lung cancer worry and at two time points (T0 and T2) for anxiety and depression. A ‘screening unaware’ community sample (n = 383) with the same age and smoking characteristics were assessed once (T0) for these measures. In the real-world setting, high-risk individuals undergoing LDCT screening had raised psychological distress, but overall variations were not likely to be clinically meaningful. Poorer psychological outcomes at T0, but not T2 after adjusting for baseline scores, were observed in correlation with following factors: being female, younger, not in paid employment, not married/cohabiting with a partner, and lower education.