Yang L, et al. - In view of the inconsistent findings concerning the association between psychological distress and risk of mortality in previous studies, researchers addressed this inconsistent association using a large US population-based cohort. Data from 1997 to 2009 US National Health Interview Survey were linked with the National Death Index through 31 December 2011 for this study. Inclusion of a total of 330,367 participants (aged ≥ 18 years) was done. During a mean follow-up period of 8.2 years, death was reported for 34,074 individuals; these included 8,320 cancer-related and 8,762 cardiovascular disease-related deaths. Psychological distress and all-cause mortality were noted to have a dose-response relationship. This highlights the necessity for early prevention strategies among individuals with potential psychological distress.