Park HY, et al. - Researchers examined patients with chronic complex regional pain syndrome (CRPS) for their psychological characteristics. Further, they investigated the relationships between psychosocial factors and pain severity. This work is identified to be the first comparing the psychological characteristics of chronic CRPS patients, healthy controls, and patients with major depressive disorder (MDD). They assessed Minnesota Multiphasic Personality Inventory (MMPI-2) profiles and scores on the Beck Depression Inventory and State–Trait Anxiety Inventory from 76 patients with CRPS, 95 patients with other types of chronic pain, 171 healthy controls, and 66 patients with MDD. For patients with CRPS, higher scores were calculated on the Hypochondriasis (Hs), Depression (D), Hysteria (Hy), Paranoia (Pa), and Psychasthenia (Pt) scales of the MMPI-2 compared to healthy controls. Lower scores were reported on the D, Psychopathic deviate (Pd), Pa, Pt, Schizophrenia (Sc), and Social introversion (Si) scales in the CRPS group vs the MDD group. CRPS patients exhibited more psychologically adaptable neurotic profiles than patients with MDD; however, both pain groups shared this profile. Findings further emphasize evaluating patients with CRPS for depressive symptoms, despite no major contribution of pain severity in depression.