Yang Y, et al. - Researchers prospectively investigated the association of the oral microbiome with subsequent colorectal cancer (CRC) risk in this nested case-control study. Participants included 231 patients with CRC and 462 control participants within the Southern Community Cohort Study, of whom 75% were African American. Findings revealed associations of multiple bacterial taxa with CRC risk. An increased risk of CRC was evident with oral pathogens Treponema denticola and Prevotella intermedia. Patients with CRC had a greater abundance of Bifidobacteriaceae, in the phylum Actinobacteria, than control participants. In the phylum Bacteroidetes, Prevotella denticola and Prevotella sp. oral taxon 300 were identified to be correlated with an increased CRC risk, while Prevotella melaninogenica was noted to be associated with a decreased risk of CRC. They also noted a decreased CRC risk in correlation with Carnobacteriaceae, Streptococcaceae, Erysipelotrichaceae, Streptococcus, Solobacterium, Streptococcus sp. oral taxon 058, and Solobacterium moorei in the phylum Firmicutes.