Lee SJ, Shin IC, Jeong IW, et al. - In this study, the impacts on microaneurysm (MA) and perifoveal perfusion were examined in nonproliferative diabetic retinopathy (NPDR) patients with macular edema (ME) after early intensive treatment using intravitreal ranibizumab (IVR) injections. Between August 2016 and February 2019, researchers prospectively included 25 eyes of 25 type 2 diabetes mellitus patients with ME. Individuals were administered 0.5-mg IVR injections monthly for 6 months. They conducted ocular assessment, including best-corrected visual acuity (BCVA; using the Early Treatment Diabetic Retinopathy Study chart), central retinal thickness (CRT; using optical coherence tomography), fundus photography, and fluorescein angiography, for all participants. At baseline, outcomes obtained were compared to those observed after 6 months. The data reveal that in NPDR patients with ME, treatment with early intensive IVR therapy not only improved BCVA and CRT but also reduced MA turnover. Nevertheless, IVR therapy did not display significant improvement in perifoveal non-perfused area in the study period of 6 months.