Holm JL, et al. - Investigators included 23 randomized controlled trials and one nonrandomized controlled study consisting of 45 treatment arms with 14 separate active substances in this study to analyze the literature concerning prophylactic regimen of elevated intraocular pressure (IOP) following uncomplicated cataract surgery. They graded 9 trials (as per the GRADE criteria) as 'high' quality of evidence, 12 trials as 'moderate', whereas 3 trials were given the grade 'low' quality of evidence. They noticed that the primary outcomes exhibited most consistency between the trials, which studied the consequence of timolol and presented a relative effect from 18.6% to 29.6% at 3–8 hr and 9.8% to 23.6% at day 1. They reported good relative IOP-lowering effect of timolol, latanoprost, and travoprost alone or medications containing timolol as an additive active essence like dorzolamide + timolol, brinzolamide + timolol and brimonidine + timolol (which could be gained by a single dose postoperatively).