Hoffmann-Vold AM, Allanore Y, Alves M, et al. - This study was sought to distinguish overall disease course, progression patterns, and risk factors predictive for progressive interstitial lung disease (ILD) in patients with systemic sclerosis-associated ILD (SSc-ILD), using data from the European Scleroderma Trials And Research database over long-term follow-up. Researchers recruited a total of 826 patients with SSc-ILD. As per the findings, SSc-ILD exhibits a heterogeneous and variable disease course, and therefore monitoring all patients closely is important. This study’s findings demonstrate that the novel treatment concepts, with treatment initiation before forced vital capacity (FVC) decline occurs, should aim for prevention of progression to avoid irreversible organ damage. They evaluated long-term progressive ILD and progression patterns in patients with multiple FVC measurements. Multivariable mixed-effect models were applied to examined potential predictors of ILD progression.