Vistisen D, et al. - Among 935 patients with type 1 diabetes and 1,984 with type 2 diabetes, researchers used repeated clinical measures for up to 16 years to measure the effect of albuminuria status on the development of estimated glomerular filtration rate (eGFR) trajectories after CKD stage 3 (CKD3) and evaluated possible heterogeneous patterns of development among a subgroup with normoalbuminuria. Data revealed that mean annual declines in eGFR for normo-, micro- and macroalbuminuria in the first 10 years following CKD3 were 1.9, 2.3, and 3.3 mL/min/1.73 m²in type 1 diabetes and 1.9, 2.1, and 3.0 in type 2 diabetes, respectively. The findings favor a diabetes-dependent decrease in kidney function without albuminuria following CKD3, with a progressive decrease seen in a subgroup. In terms of cardioprotective and renal-protective therapy, this group appears to be undertreated and indicates that more attention should be paid to normoalbuminuric diabetic kidney disease.