Chivese T, et al. - Using a cross-sectional analysis, women in Cape Town, South Africa, who had hyperglycemia first detected in pregnancy (HFDP) were followed up 5 to 6 years later in order to define the proportion of those who progressed to T2D and related risk factors. Participants (n = 220) with mean age 37.2 years were examined via a 75 g oral glucose tolerance test, anthropometric measurements, and a survey. Researchers noted progression to T2D, impaired fasting glucose, and impaired glucose tolerance in 48% (95% CI 41.2–54.4), 5.5% (95% CI 3.1–9.4), and in 10.5% (95% CI 7.0–15.3), respectively. Waist circumference, hip circumference, and BMI were identified as the factors that were related to the risk of progression to T2D, at follow-up. At baseline, insulin and oral hypoglycaemic therapy during HFDP, fasting, and oral glucose tolerance test 2-hour glucose level at HFDP diagnosis were found to be associated with the risk of progression to T2D. The findings regarding the progression to T2D emphasized the requirement for interventions to delay or prevent progression to T2D following HFDP. A possible contribution of interventions aimed at preventing HFDP to attenuating T2D risk was also suggested.