Guo W, et al. - Through an updated meta-analysis of 17,079 patients with breast cancer (BC), the researchers intended to evaluate the prognostic effect of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). Studies showed that patients with higher PLR were associated with a significantly worse prognosis. A relation between neutrophil and cancer-associated inflammation with the potential mechanism of responding to the ectopic interleukin-8 released in tumor proliferation, progression, and metastasis was observed. Furthermore, elevated PLR was correlated to shorter disease-free survival. A greater relationship between NLR and overall survival in triple-negative BC patients than in HER2-positive ones was noted. In BC patients, elevated NLR and PLR were linked with poor OS as well as high risk of recurrence. For HER2-positive BC patients, NLR and PLR had a negative prognostic value, and both are easily obtainable useful biomarkers in BC.