Prognostic value of multiparametric magnetic resonance imaging, transient elastography and blood‐based fibrosis markers in patients with chronic liver disease
Liver International Dec 04, 2020
Jayaswal ANA, Levick C, Selvaraj EA, et al. - As liver cT1, liver T1, transient elastography (TE) and blood‐based biomarkers have independently been shown to effectively predict clinical outcomes, researchers utilized a cohort of 197 patients with compensated chronic liver disease to compare their prognostic value. Participants were 61% male, had a median age of 54 years, and were were followed up for 693 patient‐years (median 43 (26‐58) months). This study’s findings demonstrate that clinical outcomes can be predicted by liver cT1, TE, and serum‐based biomarkers, but when taking into account technical failure/unreliability, TE cut‐offs perform worse than those of cT1 and blood biomarkers. NAFLD (41%), viral hepatitis (VH, 25%) and alcohol‐related liver disease (ArLD; 14%) were the most commonly diagnosed conditions. Clinical outcomes were predicted by liver cT1 > 825ms with HR 9.9, TE > 8kPa with HR 7.8 and FIB‐4 > 1.45 with HR 4.09. Liver cT1 > 825 ms could predict clinical outcomes, but TE > 8kPa could not, after analysis taking into account technical failure and unreliability.
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