Zhang Y, et al. - Researchers studied immunohistochemical (IHC) and clinicopathological features of patients with esophageal small cell carcinoma (ESCC), and determined the impact of utilization of different marker combination on prognostic outcome. They used immunohistochemistry to analyze the paraffin-embedded ESCC samples of 73 patients for neuron specific enolase (NSE), chromogranin A (CgA), synaptophysin (Syn) and thyroid transcriptional factor-1 (TTF-1). In patients, the estimated 2- and 3-year survivals were 24.8% and 19.9%, respectively. These patients had a poor prognosis. According to observations, the positive labeling of Syn, CgA, NSE and TTF-1 implicated their favourable prognostic value trend. Overall, they concluded that these factors or their combination might be useful markers in prognostic evaluation.