Charette N, et al. - Among 235 patients with chemorefractory advanced colorectal cancer (CRC) included in the SoMore and RegARd-C trials, researchers assessed the impact of body composition including both muscle mass and adipose tissue on overall survival (OS). On baseline computed tomography (CT) images, body composition was evaluated in 217 patients. They evaluated link between body composition (sarcopenia, muscle density, subcutaneous and visceral fat index and density), body mass index (BMI) and OS. A better OS was observed in patients with a higher BMI. Increased mortality was observed among those with low muscle index and muscle density. An increased risk of dying was found to be related to low subcutaneous and visceral fat index as well as a high subcutaneous and visceral adipose tissue density. Multivariate analysis revealed a high visceral fat density as the main predictor of poor survival. Overall, obesity was confirmed to have a protective role in CRC patients at an advanced stage. Findings also corroborated the negative prognostic impact of muscle depletion on survival. Visceral adipose tissue density was identified as an important prognostic factor in metastatic CRC, for the first time in this study.