Guaricci AI, et al. - In an asymptomatic population (63% male, mean age 64 ±10 years; 17.6% with diabetes), researchers assessed the incremental prognostic benefit of carotid artery disease and subclinical coronary artery disease (CAD) features over and above clinical evaluation. They assessed the performance of 10-year Framingham risk score (FRS) together with carotid ultrasound and coronary computed tomography angiography in regard to prediction of major adverse cardiac events (MACE) over a 6-year period. They found that an increased MACE prediction was provided by CAD and plaque positive remodeling vs a model based on 10-year FRS, carotid disease, and coronary artery calcium score estimates. The only predictor of MACE identified in the diabetes subgroup was percentage of segments with remodeled plaque.