Prognostic factors for 30-day mortality in critically ill patients with coronavirus disease 2019: An observational cohort study
Critical Care Medicine Dec 23, 2020
Ferrando-Vivas P, Doidge J, Thomas K, et al. - This observational cohort analysis was undertaken to determine features predictive of 30-day mortality in patients critically ill with coronavirus disease 2019 in England, Wales, and Northern Ireland. Overall 258 adult critical care units participated. Following adjustment for multiple variables with Cox proportional hazards modeling, links between the candidate prognostic factors and time to death within 30 days of the initiation of critical care were ascertained. For the following factors, experts found significant associations: age, ethnicity, deprivation, BMI, prior dependency, immunocompromise, lowest systolic blood pressure, highest heart rate, highest respiratory rate, Pao2/Fio2 ratio (and interaction with mechanical ventilation), highest blood lactate level, highest serum urea, and lowest platelet count over the first 24 hours of critical care. There existed nonsignificant links for sex, sedation, highest temperature, and lowest hemoglobin level. Herein, findings revealed patient features predictive of an elevated probability of death within 30 days of the initiation of critical care for patients suffering from coronavirus disease 2019.
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