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Prognostic factors determining survival of patients operated for non-small cell lung cancer with consideration given to morphological parameters of blood

Cancer Management and Research Jan 21, 2021

Łochowski M, Łochowska B, Chałubińska-Fendler J, et al. - Researchers investigated prognostic parameters which, in early diagnostics, could best ascertain survival of patients surgically managed for non-small cell lung cancer (NSCLC). This analysis involved 532 patients (174 women and 358 men) aged 36– 84 years (the mean age: 63.6 years) treated surgically for stage IA – III NSCLC. In univariate analysis, NLR, PLR, and LMR values, RDW-CW and CCI ranges, as well as the number of monocytes were all were shown to have an impact on patients’ overall survival. Overall, in patients operated on due to NSCLC, the following were identified as independent and significant prognostic factors: patients’ gender, RDW and PLR values, Charlson index, the number of involved N2 nodes by cancer, and postoperative complications. Specifically, male sex, CCI > 4, RDW-CV > 14.5% and PLR > 144, the number of metastatic N2 lymphatic nodes, and existence of post-operative complications were the six independent negative prognostic factors identified in the multivariate analysis.

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