Mowbray FI, Manlongat D, Costa AP, et al. - Researchers intended to synthesize the current evidence assessing the link between frailty and a series of post-arrest outcomes after the provision of cardiopulmonary resuscitation. They explored MEDLINE, PubMed (exclusive of MEDLINE), EMBASE, CINAHL, and Web of Science to identify relevant observational studies. This review involved four studies, and three were eligible for statistical pooling. The study sample included 1,134 individuals who encountered in-hospital cardiac arrest (IHCA). The Clinical Frailty Scale and adjusted age (minimum confounder) were used in three studies; about three-fold increase in the odds of dying in-hospital post-IHCA was observed in relation to the presence of frailty. Reduced incidence of return of spontaneous circulation and discharge home post-IHCA were noted in relation to frailty. Experts identified high certainty evidence demonstrating that frailty is associated with in-hospital mortality after IHCA. Frailty was recognized as a strong prognostic factor that adds useful information as well as can inform shared-decision making and policies surrounding advance care directives.