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Progesterone for prevention of preterm birth in women with short cervical length: 2‐year infant outcomes

Ultrasound in Obstetrics & Gynecology Feb 17, 2021

Cuijpers CJJ, Van't Hooft J, Schneeberger C, et al. - Children born to women with a short cervix and otherwise low risk for preterm birth, were examined for the long‐term outcomes after antenatal exposure to vaginal progesterone vs placebo. Researchers performed a follow‐up study of the Triple P trial, in which 80 low‐risk women with a short cervix (≤ 30 mm) were randomized at 18–22 weeks' gestation to progesterone (n = 41) or placebo (n = 39). The randomized women gave birth to 80 children. Of these children, one in the progesterone group and two in the placebo group died in the neonatal period. Per outcomes, offspring exposed to progesterone in the second and third trimesters of pregnancy exhibit no substantial harm, in terms of neurodevelopment and health.

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