Rodríguez-Carrio J, Coras R, Alperi-Lopez M, et al. - This research was sought to define oxylipin networks during the earliest stages of rheumatoid arthritis (RA) and evaluate their associations with clinical features and treatment outcomes. The researcher included a total of 60 patients with early RA (according to the American College of Rheumatology/European League Against Rheumatism 2010 criteria), 11 individuals with clinically suspect arthralgia, and 28 healthy control individuals. They collected serum samples at the time of onset. Via liquid chromatography-tandem mass spectrometry, a total of 75 oxylipins, mostly derived from arachidonic, eicosapentanoic, and linoleic acids were identified in the serum. It has been reported that oxylipin networks differ across stages during the earliest phases of RA. The data illustrated that these distinct oxylipin networks could potentially elucidate pathways with clinical relevance for disease progression, clinical heterogeneity, and treatment response.