van de Beek M, van Steenoven I, van der Zande JJ, et al. - In the present study, the researchers investigated clinical features, cognitive decline, and predictors for time to dementia in prodromal dementia with Lewy bodies with mild cognitive impairment (MCI-LB) vs prodromal Alzheimer disease (MCI-AD). Seventy-three MCI-LB patients (12% female; 68 ± 6 years; Mini Mental State Examination, 27 ± 2) and 124 MCI-AD patients (48% female; 68 ± 7 years; Mini Mental State Examination, 27 ± 2) from the Amsterdam Dementia Cohort were involved. For 61 MCI-LB patients and all MCI-AD patients (3 ± 2 years), follow-up was available. The most frequently present core feature in MCI-LB (69%) was parkinsonism. Cox proportional hazards regressions demonstrated that lower attention and more posterior cortical atrophy predicted shorter time to dementia in the MCI-LB patients. Worse performance on memory and executive functions were independently linked to time to Alzheimer dementia in MCI-AD patients. When compared with MCI-AD patients, MCI-LB patients have distinct neuropsychiatric and cognitive profiles with prominent declining attention. The findings highlight the importance of early diagnosis as symptoms in the prodromal stages already have an effect.