Farrugia MK, Jun Ma S, Hennon MW, et al. - For second early-stage non–small cell lung cancers (NSCLC), researchers assessed prognosis via a retrospective review of inoperable patients who received thoracic stereotactic body radiation therapy (SBRT) from February 2007 to April 2019. This study did not include cases with previous small cell lung cancers or SBRT treatments for tumors other than NSCLC. Gender, Karnofksy performance status (KPS), prior lung cancer, anticoagulation use, and history of heart disease were shown to be correlated with overall survival (OS) in univariate log-rank tests. Incorporation of these factors into a multivariate Cox regression model showed a significant association of female gender, KPS, and prior lung cancer with OS. Findings demonstrated that improved OS was achieved in relation to ablative radiotherapy for new primaries vs initial lung cancer SBRT inoperable cases. Therefore, SBRT should be offered to these patients should not be stopped.