Chalmers BP, et al. - Through retrospectively reviewed 95 patients (102 primary total knee arthroplasty {TKA}) who were treated between 2000 and 2014 with a history of prosthetic joint infection (PJI) in another TKA or total hip arthroplasty (THA), the researchers intended to contrast the risk of PJI of primary TKA in this patient population against matched controls. At ten years, the cumulative incidence of PJI in the study cohort was markedly greater than the matched cohort. Host grade was not an important risk factor for PJI, in the study group. A higher rate of PJI in patients on chronic suppression was observed, with 6-7 patients who developed PJI in the study group being on prolonged suppression. In only two of seven patients, the new infecting microorganism was the same as before. Hence, a three-fold higher risk of PJI was seen in another joint in patients who underwent a clean primary TKA with a history of TKA or THA with a ten-year cumulative incidence of 6.1%, in comparison to matched controls. In patients with chronic antibiotic suppression, the risk of PJI was 15-fold greater.