Siddiqi A, et al. - Via a retrospective review conducted for subjects at two tertiary care centers who underwent functional prosthetic spacer implantation following total knee arthroplasties (TKA) periprosthetic joint infection (one of the most common and devastating complications of TKA) as part of a functional single-stage (n=57) or all cement spacer conventional two-stage (n=137) revision arthroplasty protocol over a five-year period, the researchers intended to review the ultimate treatment success, reimplantation rates, reoperation rates and change in knee range of motion. No notable variation in reinfection, reoperation, or success rates among the one- and two-stage revision TKA cohorts was observed. The mean final total arc of motion was also alike amongst the two groups. Hence, at mid-term follow-up, functional prosthetic spacers gave the benefit of a single procedure with reduced overall hospitalization and enhanced cost-effectiveness with analogous success rates (78.9%) in contrast to two-stage exchange (70.8%). However, long-term data are needed to conclude its longevity and efficiency since the results in this study are promising.