Ricciuto A, Hansen BE, Ngo B, et al. - Researchers examined features of primary sclerosing cholangitis (PSC)-inflammatory bowel diseases (IBD) vs IBD without PSC in children. In this retrospective study, they matched each of 74 children with PSC-IBD, diagnosed from 2000 through 2018, with 2 children with ulcerative colitis or IBD-unclassified (controls) based on gender, date of birth, and type of IBD. Relative to controls, children with PSC-IBD in higher proportions had backwash ileitis, pancolitis, and rectal sparing, and more severe right-sided disease. Treatment with only 5-ASA and IBD in clinical remission were more frequent among patients with PSC-IBD, relative to controls. Patients with PSC-IBD vs controls had a lower risk of colectomy or treatment with a biologic agent. However, a lack of symptoms does not always indicate a lack of mucosal inflammation in patients with PSC-IBD. Patients with PSC-IBD showed greater growth impairments compared with controls.