Rebolj M, et al. - In comparison with contemporary primary liquid based cytology screening, researchers offered the initial report on the chief results of the prevalence and incidence rounds of a large pilot of routine primary high-risk human papillomavirus (hrHPV) tests in England. Between May 2013 and December 2014, 578,547 women were subjected to cervical screening in primary care, followed-up until May 2017; 183,970 (32%) were screened with hrHPV testing. The results obtained from the observational study indicate that routine primary hrHPV screening in England increased the detection of cervical intraepithelial neoplasia grade 3 or worse and cervical cancer by nearly 40% and 30%, respectively, vs liquid-based cytology. After three years, the very low incidence of cervical intraepithelial neoplasia grade 3 or worse support an increase in the screening interval.