Jozwiak S, Słowińska M, Borkowska J, et al. - In this prospective, nonrandomized clinical trial of 14 infants diagnosed with tuberous sclerosis complex, experts assessed the neuropsychologic and epilepsy outcomes at school age in children with tuberous sclerosis complex who received preventive antiepileptic treatment in infancy. Infants were randomized in the preventive group (n = 14) and in the standard treatment group (n = 25 of 31). In comparison with one of 25 in the standard treatment group, a clinical seizure was never noted in seven of 14 kids in the preventive group. Thus, the study gives evidence that in infants with tuberous sclerosis complex, preventive antiepileptic treatment increases long-term epilepsy control as well as the cognitive outcome at school age.