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Prevalence, trends, outcomes, and disparities in hospitalizations for nonalcoholic fatty liver disease in the United States

Annals of Gastroenterology Sep 01, 2019

Adejumo AC, Samuel GO, Adegbala OM, et al. - Researchers conducted this investigation to examine the prevalence, trends and outcomes of nonalcoholic fatty liver disease (NAFLD) hospitalizations in the United States. The National Inpatient Sample (2007-2014) identified hospitalizations with NAFLD by their ICD-9-CM codes and calculated prevalence and trends over an 8-year period among different demographic groups. The impact of sex, race and region on outcomes (mortality, discharge disposition, length of stay [LOS], and cost) were computed using generalized estimating equations (SAS 9.4) after excluding other causes of liver disease among the NAFLD cohorts (n = 210,660). According to findings, admissions with NAFLD tripled from 2007-2014 at an average rate of 79/100,000 hospitalizations/year, with a larger rate of increase among males vs females (83/100,000 vs 75/100,000), Hispanics vs Whites vs Blacks (107/100,000 vs 80/100,000 vs 48/100,000), and government-insured or uninsured patients vs privately-insured (94/100,000 vs 74/100,000). Compared with females, males had higher mortality, LOS, and cost. Compared with the privately-insured patients, uninsured had higher mortality, longer LOS, and poorer discharge disposition. Overall, the authors concluded that NAFLD hospitalizations are increasing rapidly in the US, with the burden being disproportionately higher among some demographic groups. Measures are needed to stop this ominous trend and eliminate outcome disparities among patients hospitalized with NAFLD.
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