Antonio-Villa NE, Fernández-Chirino L, Vargas-Vázquez A, et al. - From 1988-2018, an increase in the prevalence of diabetes and its subgroups has been observed in the U.S. A significant heterogeneity in diabetes, within the U.S, is indicated as these trends were different across gender, ethnicities, education, and age categories. The uprising trends of diabetes in the U.S. may be attributable to obesity burden, population aging, socioeconomic disparities, and lifestyle aspects.

• Data were collected from NHANES (1988-2018), to analyze trends of diabetes subgroups, stratified by gender, race, education level, age categories and time since diabetes diagnosis in the U.S.

• In the US, diabetes prevalence was 7.5% in 1988-1989, it rose to 13.9% in 2016-2018.

• The highest prevalence was evident among non-Hispanic Blacks.

• An increase in mild obesity-related diabetes (MOD), mild age-related diabetes (MARD), and severe-insulin deficient diabetes (SIDD) was also observed.

• MARD and SIDD increased sharply in non-Hispanic Blacks, SIDD in Mexican Americans, and MARD in non-Hispanic Whites.

• The highest increase in MOD prevalence was seen among males, persons with secondary/high school, and adults aged 40-64 years.

• There were sustained trends in diabetes subgroups post-stratifying time since diabetes diagnosis.