Tsuboi M, Evans J, Davies EP, et al. - This study attempted to evaluate the global prevalence of syphilis among men who have sex with men (MSM) using the available literature. Researchers carried out searches of MEDLINE, Embase, LILACS, and AIM databases, and Integrated Bio-Behavioral Surveillance (IBBS) reports between April 23, 2019, and Feb 1, 2020, to distinguish studies done between Jan 1, 2000, and Feb 1, 2020, with syphilis point prevalence data measured by biological assay among MSM (defined as people who were assigned as male at birth and had oral or anal sex with at least one other man in their lifetime) in this global systematic review and meta-analysis. They examined 4,339 records, 228 IBBS reports, and ten articles from other sources. They excluded 1,301 duplicate records, 2,467 records were excluded after the title and abstract screening, and 534 articles were excluded after full-text analysis. Urgent action is needed for unacceptably high syphilis prevalence among MSM.