Quilter LAS, de Voux A, Amiya RM, et al. - Researchers attempted at delineating the prevalence of neurologic and/or ocular symptoms among early syphilis (ES) cases. Further, they reported the clinical management of symptomatic cases entered in the STD Surveillance Network (SSuN) Neuro/Ocular Syphilis Surveillance project. They interviewed 9,123 patients with ES who were selected on the basis of current health department protocols in five participating SSuN jurisdictions from November 2016–October 2017. Among these, 151 (1.7%) reported ≥ 1 neurologic or ocular symptom indicating a low prevalence of self-reported neurologic and/or ocular symptoms in these cases. Further recommended diagnostic evaluation was accepted by nearly 35% of ES cases who self-reported symptoms; of these, 42% had documented abnormal cerebrospinal fluid. Treatment for neurosyphilis/ocular syphilis was provided in 95% of cases with documented abnormal cerebrospinal fluid. Among the symptomatic patients who had no documented lumbar puncture (65% of 151), 12 (12%) were provided treatment for and/or clinically diagnosed with neurosyphilis/ocular syphilis. Findings highlight the value of understanding barriers to appropriate clinical evaluation for ensuring proper management of patients with possible neurologic and/or ocular manifestations of syphilis.