Prevalence of irritable bowel syndrome-type symptoms in patients with inflammatory bowel disease in remission: A systematic review and meta-analysis
The Lancet: Gastroenterology & Hepatology Oct 09, 2020
Fairbrass KM, Costantino SJ, Gracie DJ, et al. - In patients with inflammatory bowel disease (IBD) in remission, researchers determined the prevalence of irritable bowel syndrome (IBS)-type symptoms in this this systematic review and meta-analysis to better assess the extent of this issue. In order to find prospective case-control or cross-sectional studies on the prevalence of symptoms meeting diagnostic criteria for IBS in adults with IBD in remission, Embase, Embase Classic, and MEDLINE were searched from January 1, 2012 to May 11, 2020. The pooled prevalence of IBS-type symptoms was 32.5% among 3,169 patients with IBD in remission. For those who reported IBS-type symptoms, anxiety and depression scores were significantly higher than among those who did not. In patients with IBD, the prevalence of IBS-compatible symptoms differed according to how remission was described. Though, even when strict criteria like endoscopic or histological remission were used, these symptoms were identified in roughly a quarter of patients. In patients with Crohn disease, these symptoms were more common and were associated with psychological comorbidity. In this specific group of patients, addressing psychological wellbeing might improve outcomes.
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