Vahle K, Gargano JW, Lewis RM, et al. - Researchers evaluated overall data, as well as, 10-year birth cohort-specific cervicovaginal HPV prevalence estimates (any, high-risk [HR], and non-HR) by 3-year age group among 27-59 year-old females born between 1950-1979, by utilizing data from 2003-2016 National Health and Nutrition Examination Surveys. Prevalence ratios from log-binomial models were used to compute average percent changes in HPV prevalence by 3-year age. Findings revealed a reduction in the prevalence of any HPV, from 49.9% in 27-29 year-olds to 33.8% in 57–59 year-olds, as well as in the prevalence of HR-HPV and non-HR-HPV. It was concluded that birth cohort differences alone can not explain reductions in HPV prevalence with age in these cross-sectional surveys, because links were observed across all birth cohorts. These observations are consistent with biological and behavioral explanations.